Adjuvant Activity of the Heat-Labile Enterotoxin from Enterotoxigenic Escherichia coli for Oral Administration of Inactivated Influenza Virus Vaccine
Identifieur interne : 001B57 ( Main/Exploration ); précédent : 001B56; suivant : 001B58Adjuvant Activity of the Heat-Labile Enterotoxin from Enterotoxigenic Escherichia coli for Oral Administration of Inactivated Influenza Virus Vaccine
Auteurs : Jacqueline M. Katz [États-Unis] ; Xiuhua Lu [États-Unis] ; Sarah A. Young [États-Unis] ; Judith C. Galphin [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1997.
Abstract
Alternative strategies for vaccination against influenza that elicit both systemic antibody and mucosal IgA responses are needed to improve the efficacy in protection against infection. This study demonstrated that oral delivery of inactivated influenza vaccine with the heat-labile enterotoxin (LT) from enterotoxigenic Escherichia coli elicited the spectrum of humoral and cell-mediated responses in BALB/c mice critical for the protection and recovery from influenza virus infection. Coadministration of LT with oral influenza vaccine increased antiviral serum IgG and mucosal IgA responses compared with administration of oral influenza vaccine alone. Serum hemagglutination-inhibition and neutralizing antibodies were also augmented by LT. The adjuvant potentiated protection from infection with influenza A H3N2 viruses in mouse lower and upper respiratory tracts, enabling the use of lower doses of oral vaccine. Coadministration of LT with oral inactivated influenza vaccine induced influenza virus-specific proliferative T cells, interleukin-2 production, and major histocompatibility complex class I -restricted cytotoxic T cells.
Url:
DOI: 10.1093/infdis/175.2.352
Affiliations:
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Galphin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A5D19E92A13262133312106DF8DBDE25CBBA42DF</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1093/infdis/175.2.352</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-R1G9NWKJ-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001538</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001538</idno><idno type="wicri:Area/Istex/Curation">001538</idno><idno type="wicri:Area/Istex/Checkpoint">000943</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000943</idno><idno type="wicri:doubleKey">0022-1899:1997:Katz J:adjuvant:activity:of</idno><idno type="wicri:Area/Main/Merge">001C19</idno><idno type="wicri:Area/Main/Curation">001B57</idno><idno type="wicri:Area/Main/Exploration">001B57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Adjuvant Activity of the Heat-Labile Enterotoxin from Enterotoxigenic <hi rend="italic">Escherichia coli</hi> for Oral Administration of Inactivated Influenza Virus Vaccine</title><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, Memphis</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Jacqueline Katz, Influenza Branch, Mailstop G16, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Lu, Xiuhua" sort="Lu, Xiuhua" uniqKey="Lu X" first="Xiuhua" last="Lu">Xiuhua Lu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Young, Sarah A" sort="Young, Sarah A" uniqKey="Young S" first="Sarah A." last="Young">Sarah A. Young</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Galphin, Judith C" sort="Galphin, Judith C" uniqKey="Galphin J" first="Judith C." last="Galphin">Judith C. Galphin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, Memphis</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1997-02">1997</date><biblScope unit="vol">175</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="352">352</biblScope><biblScope unit="page" to="363">363</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Alternative strategies for vaccination against influenza that elicit both systemic antibody and mucosal IgA responses are needed to improve the efficacy in protection against infection. This study demonstrated that oral delivery of inactivated influenza vaccine with the heat-labile enterotoxin (LT) from enterotoxigenic Escherichia coli elicited the spectrum of humoral and cell-mediated responses in BALB/c mice critical for the protection and recovery from influenza virus infection. Coadministration of LT with oral influenza vaccine increased antiviral serum IgG and mucosal IgA responses compared with administration of oral influenza vaccine alone. Serum hemagglutination-inhibition and neutralizing antibodies were also augmented by LT. The adjuvant potentiated protection from infection with influenza A H3N2 viruses in mouse lower and upper respiratory tracts, enabling the use of lower doses of oral vaccine. Coadministration of LT with oral inactivated influenza vaccine induced influenza virus-specific proliferative T cells, interleukin-2 production, and major histocompatibility complex class I -restricted cytotoxic T cells.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name></region><name sortKey="Galphin, Judith C" sort="Galphin, Judith C" uniqKey="Galphin J" first="Judith C." last="Galphin">Judith C. Galphin</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><name sortKey="Lu, Xiuhua" sort="Lu, Xiuhua" uniqKey="Lu X" first="Xiuhua" last="Lu">Xiuhua Lu</name><name sortKey="Young, Sarah A" sort="Young, Sarah A" uniqKey="Young S" first="Sarah A." last="Young">Sarah A. Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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